唇裂是一种先天性异常，需要专家手术修复。外科医生必须具有丰富的经验和理论知识才能进行手术，并且已经提出了人工智能（AI）方法来指导外科医生改善手术结局。如果可以使用AI来预测修复的唇唇的外观，那么外科医生可以将其用作辅助手术技术来调整其手术技术并改善结果。为了在保护患者隐私时探索这个想法的可行性，我们提出了一种基于深度学习的图像镶嵌方法，该方法能够覆盖唇裂，并产生唇彩，而无需裂缝。我们的实验是在两个现实世界中的裂口数据集上进行的，并由专家cleft唇外科医生评估，以证明该方法的可行性。

Late-life depression (LLD) is a highly prevalent mood disorder occurring in older adults and is frequently accompanied by cognitive impairment (CI). Studies have shown that LLD may increase the risk of Alzheimer's disease (AD). However, the heterogeneity of presentation of geriatric depression suggests that multiple biological mechanisms may underlie it. Current biological research on LLD progression incorporates machine learning that combines neuroimaging data with clinical observations. There are few studies on incident cognitive diagnostic outcomes in LLD based on structural MRI (sMRI). In this paper, we describe the development of a hybrid representation learning (HRL) framework for predicting cognitive diagnosis over 5 years based on T1-weighted sMRI data. Specifically, we first extract prediction-oriented MRI features via a deep neural network, and then integrate them with handcrafted MRI features via a Transformer encoder for cognitive diagnosis prediction. Two tasks are investigated in this work, including (1) identifying cognitively normal subjects with LLD and never-depressed older healthy subjects, and (2) identifying LLD subjects who developed CI (or even AD) and those who stayed cognitively normal over five years. To the best of our knowledge, this is among the first attempts to study the complex heterogeneous progression of LLD based on task-oriented and handcrafted MRI features. We validate the proposed HRL on 294 subjects with T1-weighted MRIs from two clinically harmonized studies. Experimental results suggest that the HRL outperforms several classical machine learning and state-of-the-art deep learning methods in LLD identification and prediction tasks.

在许多情况下，更简单的模型比更复杂的模型更可取，并且该模型复杂性的控制是机器学习中许多方法的目标，例如正则化，高参数调整和体系结构设计。在深度学习中，很难理解复杂性控制的潜在机制，因为许多传统措施并不适合深度神经网络。在这里，我们开发了几何复杂性的概念，该概念是使用离散的dirichlet能量计算的模型函数变异性的量度。使用理论论据和经验结果的结合，我们表明，许多常见的训练启发式方法，例如参数规范正规化，光谱规范正则化，平稳性正则化，隐式梯度正则化，噪声正则化和参数初始化的选择，都可以控制几何学复杂性，并提供一个统一的框架，以表征深度学习模型的行为。

我们解决以下动作效应预测任务。给定描绘世界初始状态和文本中表达的动作的图像，预测了动作后描绘世界状态的图像。预测应具有与输入图像相同的场景上下文。我们探讨了最近提出的GLIDE模型执行此任务的使用。Glide是一个生成性神经网络，可以合成图像的掩盖区域（涂层），以短片段为条件。我们的想法是掩盖预期动作效果的输入图像的区域。然后使用滑行以在所需动作为条件的蒙面区域内涂抹涂漆。这样，结果图像具有与输入图像相同的背景上下文，并更新以显示动作的效果。我们使用带有动作标记的自我中心视频的Epic数据集给出了实验的定性结果。

在本文中，我们研究了多服务器边缘计算中基于区块链的联合学习（BFL）的新延迟优化问题。在此系统模型中，分布式移动设备（MDS）与一组Edge服务器（ESS）通信，以同时处理机器学习（ML）模型培训和阻止开采。为了协助ML模型培训用于资源受限的MD，我们制定了一种卸载策略，使MD可以将其数据传输到相关的ESS之一。然后，我们基于共识机制在边缘层上提出了一个新的分散的ML模型聚合解决方案，以通过基于对等（P2P）基于基于的区块链通信构建全局ML模型。区块链在MDS和ESS之间建立信任，以促进可靠的ML模型共享和合作共识形成，并能够快速消除由中毒攻击引起的操纵模型。我们将延迟感知的BFL作为优化，旨在通过联合考虑数据卸载决策，MDS的传输功率，MDS数据卸载，MDS的计算分配和哈希功率分配来最大程度地减少系统延迟。鉴于离散卸载和连续分配变量的混合作用空间，我们提出了一种具有参数化优势演员评论家算法的新型深度强化学习方案。从理论上讲，我们根据聚合延迟，迷你批量大小和P2P通信回合的数量来表征BFL的收敛属性。我们的数值评估证明了我们所提出的方案优于基线，从模型训练效率，收敛速度，系统潜伏期和对模型中毒攻击的鲁棒性方面。

超越地球轨道的人类空间勘探将涉及大量距离和持续时间的任务。为了有效减轻无数空间健康危害，数据和空间健康系统的范式转移是实现地球独立性的，而不是Earth-Reliance所必需的。有希望在生物学和健康的人工智能和机器学习领域的发展可以解决这些需求。我们提出了一个适当的自主和智能精密空间健康系统，可以监控，汇总和评估生物医学状态;分析和预测个性化不良健康结果;适应并响应新累积的数据;并提供对其船员医务人员的个人深度空间机组人员和迭代决策支持的预防性，可操作和及时的见解。在这里，我们介绍了美国国家航空航天局组织的研讨会的建议摘要，以便在太空生物学和健康中未来的人工智能应用。在未来十年，生物监测技术，生物标志科学，航天器硬件，智能软件和简化的数据管理必须成熟，并编织成精确的空间健康系统，以使人类在深空中茁壮成长。

空间生物学研究旨在了解太空飞行对生物的根本影响，制定支持深度空间探索的基础知识，最终生物工程航天器和栖息地稳定植物，农作物，微生物，动物和人类的生态系统，为持续的多行星寿命稳定。要提高这些目标，该领域利用了来自星空和地下模拟研究的实验，平台，数据和模型生物。由于研究扩展到低地球轨道之外，实验和平台必须是最大自主，光，敏捷和智能化，以加快知识发现。在这里，我们介绍了由美国国家航空航天局的人工智能，机器学习和建模应用程序组织的研讨会的建议摘要，这些应用程序为这些空间生物学挑战提供了关键解决方案。在未来十年中，将人工智能融入太空生物学领域将深化天空效应的生物学理解，促进预测性建模和分析，支持最大自主和可重复的实验，并有效地管理星载数据和元数据，所有目标使生活能够在深空中茁壮成长。

In the Earth's magnetosphere, there are fewer than a dozen dedicated probes beyond low-Earth orbit making in-situ observations at any given time. As a result, we poorly understand its global structure and evolution, the mechanisms of its main activity processes, magnetic storms, and substorms. New Artificial Intelligence (AI) methods, including machine learning, data mining, and data assimilation, as well as new AI-enabled missions will need to be developed to meet this Sparse Data challenge.

We present a machine-learning framework to accurately characterize morphologies of Active Galactic Nucleus (AGN) host galaxies within $z<1$. We first use PSFGAN to decouple host galaxy light from the central point source, then we invoke the Galaxy Morphology Network (GaMorNet) to estimate whether the host galaxy is disk-dominated, bulge-dominated, or indeterminate. Using optical images from five bands of the HSC Wide Survey, we build models independently in three redshift bins: low $(0<z<0.25)$, medium $(0.25<z<0.5)$, and high $(0.5<z<1.0)$. By first training on a large number of simulated galaxies, then fine-tuning using far fewer classified real galaxies, our framework predicts the actual morphology for $\sim$ $60\%-70\%$ host galaxies from test sets, with a classification precision of $\sim$ $80\%-95\%$, depending on redshift bin. Specifically, our models achieve disk precision of $96\%/82\%/79\%$ and bulge precision of $90\%/90\%/80\%$ (for the 3 redshift bins), at thresholds corresponding to indeterminate fractions of $30\%/43\%/42\%$. The classification precision of our models has a noticeable dependency on host galaxy radius and magnitude. No strong dependency is observed on contrast ratio. Comparing classifications of real AGNs, our models agree well with traditional 2D fitting with GALFIT. The PSFGAN+GaMorNet framework does not depend on the choice of fitting functions or galaxy-related input parameters, runs orders of magnitude faster than GALFIT, and is easily generalizable via transfer learning, making it an ideal tool for studying AGN host galaxy morphology in forthcoming large imaging survey.

A long-standing goal of machine-learning-based protein engineering is to accelerate the discovery of novel mutations that improve the function of a known protein. We introduce a sampling framework for evolving proteins in silico that supports mixing and matching a variety of unsupervised models, such as protein language models, and supervised models that predict protein function from sequence. By composing these models, we aim to improve our ability to evaluate unseen mutations and constrain search to regions of sequence space likely to contain functional proteins. Our framework achieves this without any model fine-tuning or re-training by constructing a product of experts distribution directly in discrete protein space. Instead of resorting to brute force search or random sampling, which is typical of classic directed evolution, we introduce a fast MCMC sampler that uses gradients to propose promising mutations. We conduct in silico directed evolution experiments on wide fitness landscapes and across a range of different pre-trained unsupervised models, including a 650M parameter protein language model. Our results demonstrate an ability to efficiently discover variants with high evolutionary likelihood as well as estimated activity multiple mutations away from a wild type protein, suggesting our sampler provides a practical and effective new paradigm for machine-learning-based protein engineering.